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Merck

P4020

Protamine sulfate

amorphous powder

Synonym(s):

Salmine, Salmine from salmon

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About This Item

CAS Number:
53597-25-4
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00132091

Key Documents

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Product Name

Protamine sulfate salt from salmon, Grade X, amorphous powder

type

Grade X

form

amorphous powder

impurities

histone, free (Millon test)

color

white to off-white

solubility

6 M HCl: 25 mg/mL

Quality Level

200

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General description

Protamine are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. It is found to be localized to the sperm head.

Application

May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.

Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine sulfate salt from salmon has been used:
  • in the pretreament of cells to study its effect on respiratory syncytial virus infection
  • in lentivirus production
  • to derivatize it into a diazeniumdiolate NO donor

Biochem/physiol Actions

Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P4020-1G: + P4020-100G: + P4020-VAR: + P4020-BULK: + P4020-25G: + P4020-10G: + P4020-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000511414
0000511414
0000494333
0000494333
0000451787

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The design and evaluation of heparin-binding foldamers.
Sungwook Choi et al.
Angewandte Chemie (International ed. in English), 44(41), 6685-6689 (2005-08-12)
Wenjie Ouyang et al.
Human gene therapy, 32(9-10), 481-494 (2020-12-02)
β-Thalassemia is one of the most prevalent genetic diseases worldwide. The current treatment for β-thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of matched donors. Gene therapy has been developed as an alternative therapeutic option
Microarrays of lentiviruses for gene function screens in immortalized and primary cells
Bailey SN, et al.
Nature Methods, 3(2), 117-117 (2006)
Steve N Bailey et al.
Nature methods, 3(2), 117-122 (2006-01-25)
Here we describe lentivirus-infected cell microarrays for the high-throughput screening of gene function in mammalian cells. To create these arrays, we cultured mammalian cells on glass slides 'printed' with lentiviruses pseudotyped as vesicular stomatitis virus glycoprotein, which encode short hairpin
Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection
Hallak LK, et al.
Virology, 271(2), 264-275 (2000)
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Product Information Sheet - P4020

Product Information Sheet

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