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Merck

P5556

Poloxamer 188 solution

10%, sterile-filtered, BioReagent, suitable for insect cell culture

Synonym(s):

Nonionic copolymer surfactant

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12161902
PubChem Substance ID:
24898666
NACRES:
NA.75
MDL number:
MFCD00082049

Key Documents

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SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

description

non-ionic

sterility

sterile-filtered

product line

BioReagent

mol wt

average mol wt 8350

concentration

10%

technique(s)

cell culture | insect: suitable

impurities

endotoxin, tested

transition temp

cloud point ≥100

HLB

29

Quality Level

400

Related Categories

General description

Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.

Application

A nonionic copolymer surfactant

Biochem/physiol Actions

Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P5556-4L: + P5556-BULK: + P5556-PROC: + P5556-VAR: + P5556-100ML: + P5556-1000ML:

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Certificates of Analysis (COA)

Lot/Batch Number
RNBL8860
RNBL4936
RNBL1005
RNBL0449
RNBK5889

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