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Merck

P5780

Putrescine dihydrochloride

powder, BioReagent, suitable for cell culture

Synonym(s):

1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride

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About This Item

Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
333-93-7
Molecular Weight:
161.07
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24898707
EC Number:
206-375-9
Beilstein/REAXYS Number:
3906680
MDL number:
MFCD00012526
Assay:
≥97% (TLC)
Form:
powder
Quality level:
200

Key Documents

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InChI key

XXWCODXIQWIHQN-UHFFFAOYSA-N

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

SMILES string

Cl[H].Cl[H].NCCCCN

biological source

microbial, synthetic

product line

BioReagent

assay

≥97% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

280 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

Quality Level

200

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General description

Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium.

Application

Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay.

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents.
Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P5780-5G: + P5780-BULK: + P5780-VAR: + P5780-25G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7077
BCCN6067
BCCM9308
BCCM4935
BCCL4992

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Polyamines and abiotic stress in plants: a complex relationship1
Minocha R, et al.
Frontiers in Plant Science, 5, 175-175 (2014)
Putrescine is involved in Arabidopsis freezing tolerance and cold acclimation by regulating abscisic acid levels in response to low temperature
Cuevas JC, et al.
Plant Physiology, 148(2), 1094-1105 (2008)
The smell of death: evidence that putrescine elicits threat management mechanisms
Wisman A and Shrira I
Frontiers in Psychology, 6, 1274-1274 (2015)
A new assay for nerve fiber repulsion
Fassold A and Strau RH
Annals of the New York Academy of Sciences, 1193(1), 43-47 (2010)
Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors
Saunders LR and Verdin E
Molecular Cancer Therapeutics, 5(11), 2777-2785 (2006)
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