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Merck

P5891

L-Pyroglutamic acid 2-naphthylamide

≥99% (TLC), suitable for ligand binding assays

Synonym(s):

L-Pyroglutamic acid β-naphthylamide, L-Pyrrolidonyl-β-naphthylamide, N1-(2-Naphthyl)-L-pyroglutamic acid, PYR

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
22155-91-5
Molecular Weight:
254.28
NACRES:
NA.26
PubChem Substance ID:
329820238
UNSPSC Code:
12352209
EC Number:
244-809-9
MDL number:
MFCD00055911
Beilstein/REAXYS Number:
5066652

Key Documents

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Product Name

L-Pyroglutamic acid 2-naphthylamide, ≥99% (TLC)

InChI key

BZEPQNMASTUAMY-ZDUSSCGKSA-N

InChI

1S/C15H14N2O2/c18-14-8-7-13(17-14)15(19)16-12-6-5-10-3-1-2-4-11(10)9-12/h1-6,9,13H,7-8H2,(H,16,19)(H,17,18)/t13-/m0/s1

SMILES string

O=C1CC[C@H](N1)C(=O)Nc2ccc3ccccc3c2

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

2-8°C

Quality Level

200

Related Categories

Application

A substrate for pyroglutamate aminopeptidase. Used for differentiation of Group A streptococci and enterococci from other streptococci.

Biochem/physiol Actions

Pyroglutamic acid is known to participate in the gamma-glutamyl cycle. Recent studies show that a congenital metabolic error was associated with increased pyroglutamic excretion in urine.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H400

pcodes

P273

Hazard Classifications

Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P5891-100MG: + P5891-25MG: + P5891-5G: + P5891-500MG: + P5891-VAR: + P5891-BULK: + P5891-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM2607
BCCL7839
BCCK9253
BCCH0964
BCCJ1028

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Studies on the Accumulation of L-Pyroglutamic Acid in Guinea Pig Epidermis
Sverre MarsteinM.D.
The Journal of Investigative Dermatology, 74(3), 135-138 (1980)
Frida Martin et al.
Parasites & vectors, 13(1), 342-342 (2020-07-11)
Parascaris univalens is a pathogenic parasite of foals and yearlings worldwide. In recent years, Parascaris spp. worms have developed resistance to several of the commonly used anthelmintics, though currently the mechanisms behind this development are unknown. The aim of this
G A Hébert
Journal of clinical microbiology, 28(11), 2425-2431 (1990-11-01)
Reference strains and clinical isolates representing the newly defined species Staphylococcus lugdunensis and Staphylococcus schleiferi were examined with the battery of tests previously recommended (G.A. Hébert, C.G. Crowder, G.A. Hancock, W.R. Jarvis, and C. Thornsberry, J. Clin. Microbiol. 26:1939-1949, 1988)
C A Barboza et al.
Scientific reports, 9(1), 2481-2481 (2019-02-23)
Inflammatory processes and cardiovascular autonomic imbalance are very relevant characteristic of the enormous dynamic process that is a myocardial infarction (MI). In this sense, some studies are investigating pharmacological therapies using acetylcholinesterase inhibitors, such as pyridostigmine bromide (PYR), aiming to
Takahiro Tougan et al.
Malaria journal, 18(1), 8-8 (2019-01-16)
The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant
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