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Merck

P7556

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

Synonym(s):

Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex

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About This Item

NACRES:
NA.77
PubChem Substance ID:
57654558
UNSPSC Code:
12352209
MDL number:
MFCD00003658
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥65% (HPLC)

Key Documents

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InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

biological source

synthetic (organic)

product line

BioReagent

assay

≥65% (HPLC)

form

powder

concentration

≥65% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 25 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

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General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone-Water Soluble has been used:
  • for in vitro maturation of oocyte complexes
  • as a σ1R antagonist to study its effect on sigma 1 receptor
  • to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

This product is not recommended for use in binding assays.

Biochem/physiol Actions

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Packaging

Package size based on progesterone content

Other Notes

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

P7556-100MG: + P7556-BULK: + 2016179: + P7556-VAR:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
0000517869
0000517869
0000499765
0000499765
0000459417

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Ligands exert Biased Activity to regulate Sigma 1 Receptor interactions with cationic TRPA1, TRPV1 and TRPM8 channels
Cortes ME, et al.
Frontiers in Pharmacology, 10(9), 634-634 (2019)
Clinical Reproductive Medicine and Surgery, 838, 17-17 (2007)
Neurosteroid Hormones Modulate the Differentiation of Adult Human Multipotent Mesenchymal Stromal Cells
Tiftikcioglu BI, et al.
Journal of stem cell research & therapy, 4(9), 2-2 (2012)
Adding hormones sequentially could be an effective approach for IVM of dog oocytes
Evecen M, et al.
Theriogenology, 75(9), 1647-1651 (2011)
Biology of progesterone action during pregnancy recognition and maintenance of pregnancy.
Spencer T. E. and F. W. Bazer
Frontiers in Bioscience, 838, d1879-d1898 (2002)
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