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Merck

S6322

Sigma Adjuvant System®

oil

Synonym(s):

Adjuvant System, Sigma Adjuvant

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About This Item

NACRES:
NA.46
UNSPSC Code:
12352203

Key Documents

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form

oil

storage temp.

2-8°C

Quality Level

300

Application

Adjuvanticity Assay: EIA titer for test mice is at least 2X greater that that of control mice.

Biochem/physiol Actions

Sigma Adjuvant System is a stable oil-in-water emulsion that may be used as an alternative to the classical Freund′s water-in-oil emulsions. It is derived from bacterial and mycobacterial cell wall components that provide potent stimulus to the immune system.

Physical form

Each vial contains 0.5 mg Monophosphoryl Lipid A (detoxified endotoxin) from Salmonella minnesota and 0.5 mg synthetic Trehalose Dicorynomycolate in 2% oil (squalene)-Tween® 80-water.

Legal Information

Sigma Adjuvant System is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H304

Hazard Classifications

Asp. Tox. 1

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

S6322-VAR: + S6322-1VL-PW: + S6322-BULK: + S6322-1VL:

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Certificates of Analysis (COA)

Lot/Batch Number
0000520052
0000520052
0000407553
0000407553
0000329924

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Development of monoclonal antibodies specific for Ricinus agglutinins
Brandon DL and Hernlem BJ
Food and agricultural immunology, 20(1), 11-22 (2009)
Déirdre B Ní Eidhin et al.
FEMS immunology and medical microbiology, 52(2), 207-218 (2007-12-21)
Clostridium difficile is the leading cause of infectious antibiotic-associated diarrhoea, particularly among the elderly. Its surface-layer protein (SLP) was tested as a vaccine component in a series of immunization and challenge experiments with Golden Syrian hamsters, combined with different systemic
Avi-Hai Hovav et al.
Infection and immunity, 73(1), 250-257 (2004-12-25)
In this study, we examined the immunogenicity and protective efficacy of six immunodominant Mycobacterium tuberculosis recombinant antigens (85B, 38kDa, ESAT-6, CFP21, Mtb8.4, and 16kDa) in a multivalent vaccine preparation (6Ag). Gamma interferon (IFN-gamma) and monophosphoryl lipid A-trehalose dicorynomycolate (Ribi) adjuvant
Nadja Thönes et al.
Journal of virology, 82(11), 5472-5485 (2008-04-04)
Capsomeres are considered to be an alternative to viruslike particle (VLP)-based vaccines as they can be produced in prokaryotic expression systems. So far, no detailed side-by-side comparison of VLPs and capsomeres has been performed. In the present study, we immunized
Christina Schellenbacher et al.
Journal of virology, 83(19), 10085-10095 (2009-07-31)
The amino (N) terminus of the human papillomavirus (HPV) minor capsid protein L2 can induce low-titer, cross-neutralizing antibodies. The aim of this study was to improve immunogenicity of L2 peptides by surface display on highly ordered, self-assembled virus-like particles (VLP)
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Data Sheet - S6322

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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