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Merck

S9549

Superoxide dismutase–polyethylene glycol from bovine erythrocytes

lyophilized powder, ≥1,350 units/mg protein

Synonym(s):

PEG-SOD

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
MFCD00678115
Specific activity:
≥1,350 units/mg protein

Key Documents

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Product Name

Superoxide dismutase–polyethylene glycol from bovine erythrocytes, lyophilized powder, ≥1,350 units/mg protein

form

lyophilized powder

specific activity

≥1,350 units/mg protein

mol wt

5000 Da

composition

Protein, ≥20% biuret

extent of labeling

≥10 mol PEG per mol protein

storage temp.

−20°C

Quality Level

200
400

Application

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
  • in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
  • as supplement in T cell culture to investigate its effect on cytokine production
  • in the preincubation of the carotid artery sections prior to DHE treatment

Biochem/physiol Actions

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.

General description

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

Other Notes

Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing PEG plus 5% citrate buffer salts

Preparation Note

Enzyme derived

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

S9183-90ML-PW: + S9549PROC: + S9549-VAR: + S9549-BULK-N: + S9549-BULK: + S9549-PH: + S9549-1MG-PW: + S9549-1MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000434849
0000434849
SLCN9733
SLBW2963
SLBT9852

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Simone R Potje et al.
Free radical biology & medicine, 112, 587-596 (2017-09-14)
[Ru(terpy)(bdq)NO]
Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase
Li HT, et al.
Acta biochimica et biophysica Sinica, 42(3), 183-194 (2010)
Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
Supinski GS and Callahan LA
American Journal of Respiratory and Critical Care Medicine, 173(11), 1240-1247 (2006)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation
Chen W, et al.
The Journal of Biological Chemistry, 286, 13846-13851 (2011)
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