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SAB4200678

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I

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About This Item

NACRES:
NA.41
UNSPSC Code:
51111800
Clone:
COL-1, monoclonal
Species reactivity:
pig, rat, human, deer, bovine
Application:
DB, ELISA, IHC
Citations:
20
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biological source

mouse

Quality Level

300

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

COL-1, monoclonal

form

buffered aqueous solution

species reactivity

pig, rat, human, deer, bovine

concentration

~1 mg/mL

technique(s)

ELISA: suitable, dot blot: suitable, immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum, immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL1A1(1277)

General description

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.
Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogen

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Biochem/physiol Actions

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.
Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

SAB4200678-VAR: + SAB4200678-100UL: + SAB4200678-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000541661
0000541661
0000453499
0000453499
0000378307

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Overexpression of CXCR4 promotes invasion and migration of non?small cell lung cancer via EGFR and MMP?9.
Zuo J, et al.
Oncology Letters, 14(6), 7513-7521 (2017)
Deregulation of the platelet-derived growth factor β-chain gene via fusion with collagen gene COL1A1 in dermatof ibrosarcoma protuberans and giant-cell fibroblastoma.
Simon M-P, et al.
Nature Genetics, 15(10), 95-95 (1997)
María Antonia Martínez-Pascual et al.
International journal of molecular sciences, 25(14) (2024-07-27)
Androgenic alopecia (AGA) is the most common type of alopecia and its treatments involve drugs that have various adverse effects and are not completely effective. Radiofrequency-based therapies (RF) are an alternative for AGA treatment. Although there is increasing clinical evidence
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