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Merck

SAB4500329

Anti-CCR7 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C-C CKR-7, C-C chemokine receptor type 7, CC-CKR-7, CCR-7, MIP-3 β receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03455130
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
9

Key Documents

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Quality Level

100

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 42 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

P32248

UniProt accession no.

P32248

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCR7(1236)

Related Categories

General description

C-C motif chemokine receptor 7 (CCR7) also known as EBI1, is encoded by the gene mapped to human chromosome 17q12-q21.2. The encoded protein is a member of chemokine receptor family and is expressed mainly by B cells, T cells, and on activated mature dendritic cells (DCs).
CCR7 is a G protein-coupled seven-transmembrane domain receptor. It has two high-affinity ligands, secondary lymphoid chemokine (SLC) and EB11-ligand chemokine (ELC).

Immunogen

The antiserum was produced against synthesized peptide derived from human CCR7.

Immunogen Range: 170-219

Application

Anti-CCR7 antibody produced in rabbit has been used for proximity ligation assay (PLA).
Anti-CCR7 antibody produced in rabbit has been used in immunofluorescence (1:50).

Biochem/physiol Actions

C-C motif chemokine receptor 7 (CCR7) harmonizes the antigen-specific immune response by combining T cells, B cells, and dendritic cells (DCs), to form functional microenvironments in the secondary lymphoid organs. CCR7 controls trafficking of skin DC under both inflammatory and steady-state conditions. This protein is also involved in emigration pathway of mature DCs from the skin to regional lymph nodes in vivo. CCR7 oligomers function acts as a scaffolds to link distinct signaling pathways for cell migration. Interaction of CCR7 with its ligand, CCL21/6ckine is essential for preferential lymph node metastasis of gastric carcinoma.
CCR7 can stimulate the development of hepatocellular carcinoma (HCC). In human malignancies, CCR7 may act as an initiator of epithelial-mesenchymal transition (EMT).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

SAB4500329-100UG:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
61053

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Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.
Saeki H, et al.
Journal of Immunology, 162(5), 2472-2475 (1999)
Lingling Yang et al.
Experimental cell research, 371(1), 231-237 (2018-08-15)
The effects of Histone deacetylase (HDAC) inhibition on epithelial-mesenchymal transition (EMT) differs in various types of cancers. However, its function in hepatocellular carcinoma (HCC) is not well-explored. In this study, we investigated the effect of HDAC inhibition on EMT in
Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.
Hauser MA, et al.
Immunity, 44(1), 59-72 (2016)
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.
Lamy PJ, et al.
Breast Cancer Research, 13(1) (2011)
Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma.
Mashino K, et al.
Cancer Research, 62(10), 2937-2941 (2002)
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