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SML0189

Indinavir sulfate salt hydrate

Name: Indinavir sulfate salt hydrate
Brand: SIGMA

≥98% (HPLC), powder, antiretroviral agent

Synonym(s):

2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate hydrate, Crixivan hydrate, L-735,524 hydrate, MK-639 hydrate

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About This Item

Empirical Formula (Hill Notation):

C₃₆H₄₇N₅O₄·H₂SO₄ · xH₂O

Molecular Weight:

711.87 (anhydrous basis)

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Product Name

Indinavir sulfate salt hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

H₂O: ≥15 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

Description

Application

Indinavir sulfate salt hydrate may be used in HIV-related cell signaling studies.

Biochem/physiol Actions

Indinavir sulfate is an antiretroviral; HIV Protease Inhibitor

Indinavir sulfate is an antiviral HIV protease inhibitor.

Indinavir sulfate suppresses the replication of HIV and is an important component of antiretroviral therapy for initial treatment of HIV infection. It is known to cause renal and urologic toxicity.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

SML0189-VAR: + SML0189-50MG: + SML0189-BULK: + SML0189-10MG:

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Renal disease associated with antiretroviral therapy in the treatment of HIV.

Ryan D Cooper et al.

Nephron. Clinical practice, 118(3), c262-c268 (2011-01-08)

The introduction of potent combination antiretroviral therapy (ART) in the treatment of HIV infection has permitted reliable control of disease progression and has markedly improved survival among people with HIV. As a result, health care providers and patients have shifted

Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake.

Benjamin Seyer et al.

Journal of neurochemistry, 153(4), 485-494 (2019-09-27)

Ethyl2-acetylamino-7-hydroxy-4-pyridin-3-yl-4H-chromene-3-carboxylate (HFI-419), the benzopyran-based inhibitor of insulin-regulated aminopeptidase (IRAP), has previously been shown to improve spatial working and recognition memory in rodents. However, the mechanism of its cognitive-enhancing effect remains unknown. There is a close correlation between dendritic spine density