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Merck

T0251

Thymidine 5′-triphosphate sodium salt

≥96%

Synonym(s):

TTP, dTTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O14P3Na
CAS Number:
18423-43-3
Molecular Weight:
504.15
UNSPSC Code:
41106305
PubChem Substance ID:
24899873
NACRES:
NA.51
MDL number:
MFCD00080338
Assay:
≥96%
Storage temp.:
−20°C

Key Documents

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Product Name

Thymidine 5′-triphosphate sodium salt, ≥96%

SMILES string

[NaH].[P](=O)(O[P](=O)(OCC1OC(CC1O)N2C=C(C(=O)NC2=O)C)O)(O[P](=O)(O)O)O

InChI

1S/C10H17N2O14P3.Na.H/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18);;

InChI key

KAELIXTVSANDSE-UHFFFAOYSA-N

assay

≥96%

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

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Application

Thymidine 5′-triphosphate (dTTP) is one of the four natural deoxynucleotides, along with deoxyadenosine 5′-triphosphate (dATP), deoxyguanosine 5′-triphosphate (dGTP) and deoxycytosine 5′-triphosphate (dCTP) used for the biosynthesis of deoxyribonucleic acids by DNA polymerases and reverse transcriptases. Deoxy-TTP may also be used as a substrate to study the specificity and kinetics of thymidine-triphosphatase(s) (EC 3.6.1.39) and other dTTP hydrolyzing activities.
Thymidine 5′-triphosphate sodium salt has been used:
  • in the quenching ability test for dual-aptamer and multiple-nucleotide detection based on a multiple-aptamer/GO-nS complex
  • to study protein-metabolite interactions in the central metabolism of Escherichia coli
  • in a polymerase chain reaction (PCR) product formation using AM-toxin primers

Biochem/physiol Actions

Thymidine triphosphate is a building block of DNA. It acts as an allosteric regulator of other nucleotides′ metabolism.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Substances Subject to be Indicated Names

ishl_indicated

Substances Subject to be Notified Names

ishl_notified

T0251-250MG:4548174009031 + T0251-50MG:4548174009055 + T0251-25MG:4548174009048 + T0251-10MG:4548174009024 + T0251-VAR: + T0251-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000528924
0000528923
0000528921
0000528925
0000528924

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Maria Eugenia Davola et al.
Methods in enzymology, 635, 231-250 (2020-03-04)
Among the many immunotherapies being developed and tested both preclinically and clinically, oncolytic viruses (OVs) are gaining traction as a forerunner in the search for potent new therapeutic agents, with a genetically engineered herpes simplex virus type 1 (HSV-1) recently
Hidenori Nakaoka et al.
The Journal of biological chemistry, 287(1), 619-627 (2011-11-17)
The Ctc1-Stn1-Ten1 (CST) complex is an RPA (replication protein A)-like protein complex that binds to single-stranded (ss) DNA. It localizes at telomeres and is involved in telomere end protection in mammals and plants. It is also known to stimulate DNA
Interconversion of deoxyribonucleotides
Henderson JF and A.R.P.Paterson
Nucleosides, 247-259 (2018)
Xue-Ke Zhao et al.
PloS one, 11(12), e0167451-e0167451 (2016-12-03)
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has
Merel M C Lambregts et al.
PloS one, 14(1), e0208819-e0208819 (2019-01-03)
Blood cultures are considered the gold standard to distinguish bacteremia from non-bacteremic systemic inflammation. In current clinical practice, bacteraemia is considered unlikely if blood cultures have been negative for 48-72 hours. Modern BC systems have reduced this time-to-positivity (TTP), questioning
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