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Merck

T1019

(±)-Thiopental

Synonym(s):

5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal

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About This Item

Empirical Formula (Hill Notation):
C11H18N2O2S
CAS Number:
76-75-5
Molecular Weight:
242.34
NACRES:
NA.77
PubChem Substance ID:
24899925
UNSPSC Code:
41116107
EC Number:
200-984-3
MDL number:
MFCD00057564

Key Documents

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InChI key

IUJDSEJGGMCXSG-UHFFFAOYSA-N

InChI

1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

SMILES string

CCCC(C)C1(CC)C(=O)NC(=S)NC1=O

drug control

USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

ethanol: complete 50 mg/mL

originator

Abbott

Quality Level

200

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Related Categories

Application

(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.

Biochem/physiol Actions

Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T1019-10MG: + T1019-VAR: + T1019-5MG: + T1019-BULK: + T1019-50MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000521590
0000521590
0000502222
0000502222
0000464814

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B M Jucker et al.
The Journal of biological chemistry, 272(16), 10464-10473 (1997-04-18)
The effects of increased plasma free fatty acids (FFA) on insulin-dependent whole body glucose disposal, skeletal muscle glycolysis, glycogen synthesis, pyruvate versus FFA/ketone oxidation, and glucose 6-phosphate (Glu-6-P) were investigated in the awake rat. A control group (glycerol-infused) and high
Cerebral circulation and metabolism during thiopental anesthesia and hyper-ventilation in man.
E C PIERCE et al.
The Journal of clinical investigation, 41, 1664-1671 (1962-08-01)
Anna Rosati et al.
Neurology, 79(24), 2355-2358 (2012-12-01)
To evaluate the efficacy and safety of ketamine (KE) in the management of refractory convulsive status epilepticus (RSE) in children. In November 2009, we started using KE for treating all children consecutively referred for RSE. Clinical and treatment data were
Colleen K Loo et al.
Journal of affective disorders, 142(1-3), 233-240 (2012-08-04)
Preliminary evidence suggests that the use of ketamine during electroconvulsive therapy (ECT) may be neuroprotective against cognitive impairment and have synergistic antidepressant effects. This study tested whether the addition of ketamine reduced cognitive impairment and enhanced efficacy over a course
Fong Huynh et al.
Therapeutic drug monitoring, 31(2), 153-169 (2009-01-30)
Thiopental is a barbiturate used in traumatic brain injuries (TBIs) to reduce intracranial pressure (ICP) and to manage cerebral ischemia. As thiopental follows Michaelis-Menten kinetics, therapeutic drug monitoring (TDM) has been used in practice to improve efficacy and reduce adverse
View All Related Papers

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