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Merck

T1157

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

Synonym(s):

Vitamin E acetate

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About This Item

Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
58-95-7
Molecular Weight:
472.74
PubChem Substance ID:
24899940
eCl@ss:
34058007
UNSPSC Code:
12352205
NACRES:
NA.75
EC Number:
200-405-4
MDL number:
MFCD00072052

Key Documents

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InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

biological source

plant

description

Synthesized from natural α-tocopherol

product line

BioReagent

form

liquid (or semi-solid)

specific activity

~1360 IU/g

mol wt

Mw 472.74 g/mol

purified by

crystallization

technique(s)

cell culture | insect: suitable

color

white to yellow

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

storage temp.

room temp

Quality Level

200

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General description

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:
  • as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
  • as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
  • as a component of serum-free medium for human colon tissue organ culture
  • to test its antioxidant effects on cow articular chondrocytes

Use in insect cell culture applications as an antioxidant.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Disclaimer

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T1157-BULK: + T1157-1G: + T1157-VAR: + T1157-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000481858
0000481858
0000464155
0000464155
0000461969

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Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Dan Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
Role of vitamin E-acetate on cisplatin induced genotoxicity: An in vivo analysis
Mazumdar M, et al.,
Central European Journal of Biology, 7(2), 334-342 (2012)
Horst Claassen et al.
Cell and tissue research, 319(3), 439-445 (2005-01-26)
Osteoarthritis (OA) is aggravated in menopausal women possibly because of changed serum estrogen levels. Estradiol has been postulated to affect oxidative stress induced by reactive oxygen species (ROS) in articular chondrocytes. We generated ROS in cultured bovine articular chondrocytes by
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