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Merck

T3309

Transferrin human

≥98%

Synonym(s):

Siderophilin, partially saturated

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About This Item

CAS Number:
11096-37-0
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
MFCD00132442
Form:
powder
Assay:
≥98%
Biological source:
human

Key Documents

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biological source

human

assay

≥98%

form

powder

Iron content

300-600 ppm

technique(s)

cell culture | stem cell: suitable

impurities

≤1.0 EU/mg endotoxin

UniProt accession no.

P02787

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... TF(7018)

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General description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Application

Transferrin has been used:
  • in isolation of epidermal stem cells and cell expansion
  • to study the effect of compound treatment on transferrin uptake
  • for transferrin uptake and confocal imaging

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.

Analysis Note

Purity by agarose electrophoresis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T3309-BULK: + T3309-1G: + T3309-VAR: + T3309-100MG: + T3309-500MG:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL5639
BCCK3472
BCCJ7138
BCCF8976
BCCF3212

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TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia
Shamsian BS, et al.
Pediatric Hematology and Oncology, 26(5), 356-362 (2009)
Nutritional issues in the patient with diabetes and foot ulcers
LITCHFORD MD
Levin and O'Neal's The Diabetic Foot, 199-217 (2008)
Non-invasive in vivo imaging of near infrared-labeled transferrin in breast cancer cells and tumors using fluorescence lifetime FRET
Abe K, et al.
PLoS ONE, 8(11), e80269-e80269 (2013)
A Djeha et al.
British journal of haematology, 80(2), 235-241 (1992-02-01)
The effect of different forms of iron and iron-binding proteins on the proliferative response of human lymphocytes to phytohaemagglutinin (PHA) has been studied. Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but
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Product Information Sheet - T3309

Product Information Sheet

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