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Merck

T3705

Transferrin human

Optiferrin™, recombinant, expressed in rice

Synonym(s):

Optiferrin™

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About This Item

CAS Number:
11096-37-0
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
MFCD00132442
Form:
powder
Assay:
≥95% (agarose gel electrophoresis)
Biological source:
human
Recombinant:
expressed in rice

Key Documents

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biological source

human

recombinant

expressed in rice

assay

≥95% (agarose gel electrophoresis)

form

powder

composition

Protein, ≥90%

Iron content

≥300 μg/g

technique(s)

immunoprecipitation (IP): suitable, tissue culture: suitable

impurities

≤1.0 EU/mg Endotoxin

UniProt accession no.

P02787

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TF(7018)

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General description

Transferrin is an 80 kDa serum glycoprotein, which is expressed in hepatocytes. The gene is located on human chromosome 3q22.1.
Optiferrin™ is recombinant human transferrin that is completelyblood-free. Optiferrin’s performance is equivalent to human holo transferrin incell culture and offers significant regulatory advantages due to its safety andconsistency. Optiferrin is suitable for a broad range of cell types thatinclude stem, primary, and bioproduction cells.

Application

Transferrin Human has been used to perform immunoprecipitation measurements. It has also been used for the preparation of essential 8 medium.

Biochem/physiol Actions

Human transferrin was shown to promote allogeneic chimerism in mice after irradiation and transplantation of incompatible bone marrow.
Transferrin facilitates the transfer of iron to erythron and peripheral tissues. It stimulates the proliferation of human lymphocytes. Mutations in this gene are linked to atransferrinemia.

Other Notes

1). Patent Rights
U.S. Patent No. 9,321,828
2). Registered Trademark Rights
U.S. Reg. 3,880,881
International Reg. 1,466,509

Legal Information

rhTF manufactured in the USA by InVitria US Pat 9321828
Optiferrin is a trademark of InVitria

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T3705-BULK: + T3705-VAR: + T3705-5G: + T3705-1G:

jan

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Certificates of Analysis (COA)

Lot/Batch Number
0000527730
0000527730
0000517286
0000517286
0000501119

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E Axelman et al.
Thrombosis and haemostasis, 112(3), 466-477 (2014-07-18)
Heparanase is implicated in cell invasion, tumour metastasis and angiogenesis. It forms a complex and enhances the activity of the blood coagulation initiator - tissue factor (TF). We describe new peptides derived from the solvent accessible surface of TF pathway
A remote-controlled immunochemical system for nephelometric detection of human serum transferrin
Strzelak K and Koncki R
Biosensors And Bioelectronics, 127(2), 31-37 (2019)
Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells
Burridge PW, et al.
Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et al.], 87(1), 21-23 (2015)
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