Skip to Content
Merck

T8325

TDZD-8

≥98% (HPLC), needles

Synonym(s):

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C10H10N2O2S
CAS Number:
327036-89-5
Molecular Weight:
222.26
NACRES:
NA.77
PubChem Substance ID:
329826879
UNSPSC Code:
12352200
MDL number:
MFCD04973552
Assay:
≥98% (HPLC)
Form:
needles
Quality level:
100
Storage condition:
protect from light

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

SMILES string

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI key

JDSJDASOXWCHPN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

needles

storage condition

protect from light

color

white

mp

63-64.4 °C

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Biochem/physiol Actions

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.
TDZD-8 is a selective inhibitor of GSK-3.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T8325-5MG: + T8325-VAR: + T8325-25MG: + T8325-BULK:

jan

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000191674
0000191674
0000128588
0000123289
0000036563

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Teng Jiang et al.
Inflammation, 41(3), 811-823 (2018-01-25)
As a recently identified susceptibility gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response.
Yujia Wang et al.
Perfusion, 33(8), 679-686 (2018-07-11)
Sevoflurane has been shown to protect against myocardial ischemia/reperfusion (I/R) injury in animals, while its cardioprotection is lost if the ischemic insult is too long. In this study, we proposed a prevailing hypothesis that GSK-3β inhibitor-mediated activation of GSK-3β/β-catenin signaling
Qing Yu et al.
Cell death & disease, 15(1), 73-73 (2024-01-19)
Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer's disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion.
Jun Yoshida et al.
Lipids, 52(3), 295-301 (2017-02-15)
Many uncommon non-methylene-interrupted fatty acids (NMI FA) are present in limpet gonads, but their biological properties remain unknown. To investigate new biological effects of naturally occurring NMI FA in eukaryotic cells, the biological activities of structurally analogous (4Z,15Z)-octadecadienoic acid (1)
Lydia Hannou et al.
Journal of biological rhythms, 33(2), 166-178 (2018-04-20)
NEUROLIGIN-1 (NLGN1) is a postsynaptic adhesion molecule involved in the regulation of glutamatergic transmission. It has been associated with several features of sleep and psychiatric disorders. Our previous work suggested that transcription of the Nlgn1 gene could be regulated by
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service