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T8931

Thyrotropic hormone from bovine pituitary

Synonym(s):

TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

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About This Item

CAS Number:
9002-71-5
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00166060

Key Documents

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biological source

bovine pituitary glands

form

powder

packaging

vial of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01223, P16473

storage temp.

2-8°C

Quality Level

200

Gene Information

cow ... TSHB(281552)
human ... TSHR(7253)

General description

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

Application

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

Biochem/physiol Actions

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Analysis Note

Contains phosphate buffer salts

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

T8931-10VL: + T8931-VAR: + T8931-1VL: + T8931-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000521653
0000521653
0000507505
0000507505
0000502840

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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
Concentration of thyrotropic hormone in persons occupationally exposed to lead, cadmium and arsenic
Jurdziak M, et al.
Biological trace element research, 182(2), 196-203 (2018)
Roberto Rocchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(14), 6019-6024 (2007-03-29)
Bacterial infections and other pathologic conditions induce complex dysfunctions of the hypothalamic-pituitary-thyroid axis, collectively known as nonthyroidal illness (NTI). To explore the pathogenesis of bacterial NTI, we injected Mycobacterium tuberculosis extracts or Escherichia coli LPS in mice lacking key components
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