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Merck

U5625

Uridine 5′-diphosphoglucuronic acid ammonium salt

98-100%, from Saccharomyces cerevisiae, powder

Synonym(s):

UDP-GlcA, UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid ammonium salt

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O18P2 · xNH3
CAS Number:
43195-60-4
Molecular Weight:
580.29 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24900657
NACRES:
NA.51
Assay:
98-100%
Biological source:
Saccharomyces cerevisiae, enzyme from bovine liver (catalase), enzyme from rabbit muscle (LDH)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

Key Documents

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Product Name

Uridine 5′-diphosphoglucuronic acid ammonium salt, 98-100%

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

biological source

Saccharomyces cerevisiae, enzyme from bovine liver (catalase), enzyme from rabbit muscle (LDH)

assay

98-100%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Related Categories

General description

Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD+) intracellularly by the catalytic activity of UDPglucose dehydrogenase. The concentration of UDPGA in a number of liver preparations ranges from 0.3-0.5 mM.

Application

Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards 14C-testosterone in the liver S9 protein. It is suitable for use in UDGPT assay.

Biochem/physiol Actions

Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

U5625-100MG: + U5625-25MG: + U5625-BULK: + U5625-500MG: + U5625-5MG: + U5625-1G: + U5625-10MG: + U5625-VAR: + U5625-250MG: + U5625-2G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000516182
0000516182
0000501371
0000501365
0000501366

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Ankit Parikh et al.
International journal of pharmaceutics, 515(1-2), 490-500 (2016-11-05)
Edaravone (EDR), a strong free radical scavenger, is known for its promising therapeutic potential in oxidative stress (OS) associated diseases, however poor oral bioavailability is the major obstacle in its potential use. Oral liquid dosage form is the most preferred
Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels
Kuriyama SN, et al.
Toxicology, 242(1-3), 80-90 (2007)
Walker's Pediatric Gastrointestinal Disease, 768-768 (2008)
Malgorzata Szultka-Mlynska et al.
Analytical and bioanalytical chemistry, 408(29), 8273-8287 (2016-10-25)
High performance liquid chromatography coupled with triple-quadrupole mass spectrometry was applied in the determination of in vitro metabolism products of selected antibiotic drugs (cefotaxime, ciprofloxacin, fluconazole, gentamicin, clindamycin, linezolid, and metronidazole). The analytes were separated on a reversed phase C18
Päivi Hirvensalo et al.
Clinical pharmacology and therapeutics, 104(1), 158-168 (2017-09-25)
To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide variation (SNV), strongly linked with UGT1A3*2, associated with reduced area under the
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