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Merck

Z0153

ZM 241385

≥98% (HPLC), adenosine A2A antagonist, powder

Synonym(s):

4-(-2-[7-amino-2-{2-furyl}{1,2,4}triazolo{2,3-a} {1,3,5}triazin-5-yl-amino]ethyl)phenol

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About This Item

Empirical Formula (Hill Notation):
C16H15N7O2
CAS Number:
139180-30-6
Molecular Weight:
337.34
UNSPSC Code:
12352200
PubChem Substance ID:
329831597
NACRES:
NA.77
MDL number:
MFCD00908394
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

ZM 241385, ≥98% (HPLC)

SMILES string

Nc1nc(NCCc2ccc(O)cc2)nc3nc(nn13)-c4ccco4

InChI key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

InChI

1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: >15 mg/mL

storage temp.

room temp

Quality Level

100

Related Categories

Biochem/physiol Actions

ZM 241385 is a potent selective adenosine A2A antagonist.
ZM 241385 is a potent selective adenosine A2A antagonist. The A2A receptor plays a role in regulating myocardial oxygen consumption and coronary blood flow and is highly expressed in the brain, where it has important roles in the regulation of glutamate and dopamine release. ZM 241385 has neuroprotective effects and is being investigated for use in Parkinson′s and other neurodegenerative disorders.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Z0153-25MG: + Z0153-VAR: + Z0153-5MG: + Z0153-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000514974
0000514971
0000514971
0000514974
0000457632

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Tarek K Motawi et al.
Molecular and cellular biochemistry, 465(1-2), 89-102 (2019-12-11)
Parkinson's disease (PD) is the second common age-related neurodegenerative disease. It is characterized by control loss of voluntary movements control, resting tremor, postural instability, bradykinesia, and rigidity. The aim of the present work is to evaluate curcumin, niacin, dopaminergic and
Chiara Zoppellaro et al.
PloS one, 8(8), e72648-e72648 (2013-09-10)
Adenosine plays an important role in regulating intestinal motility and inflammatory processes. Previous studies in rodent models have demonstrated that adenosine metabolism and signalling are altered during chronic intestinal inflammatory diseases. However, the involvement of the adenosinergic system in the
Krystyna Gołembiowska et al.
Neurotoxicity research, 22(2), 150-157 (2012-03-13)
It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that
Fabrizio Vincenzi et al.
PloS one, 7(6), e39317-e39317 (2012-07-05)
A(3) adenosine receptors (ARs) play a pivotal role in the development of cancer and their activation is involved in the inhibition of tumor growth. The effects of pulsed electromagnetic fields (PEMFs) on cancer have been controversially discussed and the detailed
Sergey Ryzhov et al.
Journal of the American Heart Association, 8(13), e010874-e010874 (2019-06-27)
Background Patients resuscitated from cardiac arrest ( CA ) have highly variable neurological, circulatory, and systemic ischemia-reperfusion injuries. After the initial hypoxic-ischemic insult, a cascade of immune and inflammatory responses develops and is often fatal. The role of the immune
View All Related Papers

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