Millipore Sigma Vibrant Logo

100050 1400W - CAS 214358-33-5 - Calbiochem

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM).

1400W - CAS 214358-33-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: N-(3-Aminomethyl)benzylacetamidine, 2HCl

Primary Target: iNOS
View This Product on Sigma-Aldrich
100050
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
214358-33-5C₁₀H₁₅N₃ · 2HCl

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
100050-5MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 5 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
      Catalogue Number100050
      Brand Family Calbiochem®
      SynonymsN-(3-Aminomethyl)benzylacetamidine, 2HCl
      References
      ReferencesParmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
      Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
      Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
      Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
      Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
      Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.
      Product Information
      CAS number214358-33-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₅N₃ · 2HCl
      Chemical formulaC₁₀H₁₅N₃ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetiNOS
      Primary Target IC<sub>50</sub>Kd = 7 nM against inducible nitric oxide synthase (iNOS)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      100050-5MGCN 04055977226867

      Documentation

      1400W - CAS 214358-33-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      1400W - CAS 214358-33-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      100050

      参考資料

      参考資料の概要
      Parmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
      Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
      Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
      Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
      Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
      Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.

      カタログ

      タイトル
      Pathways and Biomarkers of Oxidative Stress

      引用

      Title
    • Peyssonnaux, C., et al. 2005. The Journal of Clinical Investigation 115, 1860.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsN-(3-Aminomethyl)benzylacetamidine, 2HCl
      DescriptionA selective, irreversible, slow, tight binding inhibitor of inducible nitric oxide synthase (iNOS, Kd = 7 nM) both in vitro and in vivo. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number214358-33-5
      Chemical formulaC₁₀H₁₅N₃ · 2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityMethanol (5 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesParmentier, S., et al. 1999. Br. J. Pharmacol. 127, 546.
      Cardenas, A., et al. 1998. Eur. J. Pharmacol. 354, 161.
      Parrino, P.E., et al. 1998. Ann. Thorac. Surg. 66, 733.
      Garvey, E.P., et al. 1997. J. Biol. Chem. 272, 4959.
      Laszlo, F., and Whittle, B.J. 1997. Eur. J. Pharmacol. 334, 99.
      Thomsen, L.L., et al. 1997. Cancer Res. 57, 3300.
      Citation
    • Peyssonnaux, C., et al. 2005. The Journal of Clinical Investigation 115, 1860.
      		•