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171256 AMPK Activator - CAS 849727-81-7 - Calbiochem

171256
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概要

Replacement Information

主要スペック表

Empirical FormulaCAS #
C₂₂H₂₁FO₄ 849727-81-7

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171256-5MGCN
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      ガラスビン 5 mg
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      Description
      OverviewA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
      Catalogue Number171256
      Brand Family Calbiochem®
      Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
      References
      ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.
      Product Information
      CAS number849727-81-7
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₂₂H₂₁FO₄
      Chemical formulaC₂₂H₂₁FO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAMPK
      Primary Target IC<sub>50</sub>EC50 = 11.7 µM enhancing glucose uptake in L6 myocytes
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPK Activator - CAS 849727-81-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      AMPK Activator - CAS 849727-81-7 - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      171256

      参考資料

      参考資料の概要
      Kosaka, T., et al. 2005. Anal. Chem. 77, 2050.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-April-2008 RFH
      Synonyms5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
      DescriptionA cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number849727-81-7
      Chemical formulaC₂₂H₂₁FO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKosaka, T., et al. 2005. Anal. Chem. 77, 2050.