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MABF191 Anti-CSF1 Antibody, clone 2D10

MABF191
100 µL  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMABF191
      DescriptionAnti-CSF1 Antibody, clone 2D10
      Alternate Names
      • Macrophage colony-stimulating factor 1
      • CSF-1
      • M-CSF
      • MCSF
      • Lanimostim
      • Processed macrophage colony-stimulating factor 1
      Background InformationMacrophage colony stimulating factor 1 (CSF1,CSF-1, M-CSF, MCSF) or Lanimostim is a cytokine that was first identified as a molecule that plays an important role in the survival, proliferation and differentiation of mononuclear cells such as phagocytes, macrophages and monocytes. Today however we know that CSF1 also serves several other functions in a variety of cell types. CSF1 is essential for normal bone development, osteoclast proliferation, and the resorption of bone. CSF1 is released by osteoclasts upon stimulation by parathyroid hormone. Additionally CSF1 impacts actin and cytoskeleton reorganization which effects cell adhesion and migration, and overstimulation of CSF1 in endothelial cells is linked to the development and progression of atherosclerosis. CSF1 is also highly expressed in the endometrial epithelium of the pregnant uterus and CSF1 is essential for normal embryonic implantation and placental development. CSF1 appears to play an important role in cancer as well; first CSF1 is an anti-tumor agent and increases macrophage expression of anti-tumor activity, but over expression of CSF1 in breast, bone, and several other forms of cancer appears to promote cell invasiveness, proliferation, and tumor survival. Finally, CSF1 as a secreted mature factor promotes the release of proinflammatory cytokines and serves as part of the innate immunity process for inflammation and infection. CSF1 is initially produced as a precursor that is membrane bound but processed and secreted upon stimulation. CSF1 is heavily glycosylated and found both in the ECM as well as surface membranes of cells. CSF1 receptor is found on numerous cell types including macrophages, endothelial cells, and osteoclasts. EMD-Millipore’s Anti-CSF1 mouse monoclonal antibody has been tested in western blot on recombinant protein and in paraffin embedded immunohistochemistry on human placental tissue sections.
      References
      Product Information
      FormatAscites
      Control
      • Human recombinant CSF1 protein
      PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CSF1 Antibody, clone 2D10 is a highly specific mouse monoclonal antibody, that targets CSF1 & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected CSF1 in human placenta tissue.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified recombinant fragment of human CSF1 expressed in E. Coli.
      Clone2D10
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • CSF1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~60 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human recombinant CSF1 protein.

      Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected human recombinant CSF1 protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CSF1 Antibody, clone 2D10 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-CSF1 Antibody, clone 2D10 試験成績書(CoA)

      タイトルロット番号
      Anti-CSF1, clone 2D10 - VP1401153VP1401153
      Anti-CSF1, clone 2D10 - QVP1305202QVP1305202
      Anti-CSF1, clone 2D10 - VP1907183VP1907183
      Anti-CSF1, clone 2D10 -VP1410072VP1410072
      Anti-CSF1, clone 2D10 -VP1605048VP1605048
      Anti-CSF1, clone 2D10 Monoclonal AntibodyVP180170
      Anti-CSF1, clone 2D10 Monoclonal AntibodyVP1802020