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MABE164 Anti-ID4 Antibody, clone DML07

MABE164
100 µg  
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      概要

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE164
      DescriptionAnti-ID4 Antibody, clone DML07
      Alternate Names
      • DNA-binding protein inhibitor ID-4
      • Class B basic helix-loop-helix protein 27
      • bHLHb27
      • Inhibitor of DNA binding 4
      Background InformationID4 is an inhibitor of differentiation protein, which, along with ID1, ID2 and ID3, plays a key role in the regulation of lineage commitment, cell fate decisions and in the timing of differentiation during neurogenesis, lymphopoiesis and neovascularisation (angiogenesis). ID proteins, induced by the bone morphogenic protein-SMAD pathway, have also been shown to cooperate with LIF to ensure that embryonic stem cells opt for self-renewal.
      References
      Product Information
      FormatPurified
      Control
      • Human lung tissue lysate
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-ID4 Antibody, clone DML07 (Mouse Monoclonal Antibody) validated in WB to detect ID4 also known as DNA-binding protein inhibitor ID-4, Class B basic helix-loop-helix protein 27, bHLHb27.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: 1 µg/mL from a representative lot detected ID4 on 10 µg of mouse lymph node tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human ID4.
      CloneDML07
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTranscription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM].
      Gene Symbol
      • ID4
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.

      SUBUNIT STRUCTURE: Heterodimer with other HLH proteins.

      SUBCELLULAR LOCATION: Nucleus.

      SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected ID4 on 10 µg of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-ID4 Antibody, clone DML07 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-ID4 Antibody, clone DML07 試験成績書(CoA)

      タイトルロット番号
      Anti-ID4, clone DML07 - 21933552193355
      Anti-ID4, clone DML07 - 32022783202278
      Anti-ID4, clone DML07 - NRG1904653NRG1904653
      Anti-ID4, clone DML07 Monoclonal Antibody3109184
      Anti-ID4, clone DML07 Monoclonal Antibody2926477
      Anti-ID4, clone DML07, Monoclonal Antibody2840150

      カタログ

      タイトル
      New Products: Volume 3, 2012