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MABF33 Anti-MHC class II (I-A/I-E) Antibody, clone M5/114

MABF33
100 µg  
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      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, FC, IHC R Purified Monoclonal Antibody
      Description
      Catalogue NumberMABF33
      DescriptionAnti-MHC class II (I-A/I-E) Antibody, clone M5/114
      Alternate Names
      • CD74 molecule, major histocompatibility complex, class II invariant chain
      • Ia-associated invariant chain
      • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
      • gamma chain of class II antigens
      • Ia antigen-associated invariant chain
      • MHC HLA-DR gamma chain
      • HLA class II histocompatibility antigen gamma chain
      • HLA-DR antigens-associated invariant chain
      • HLA-DR-gamma
      • CD74 antigen
      Background InformationMHC class II-associated invariant chain (I-A/I-E), also known as Ia antigen-associated invariant chain, are single-pass type II membrane glycoproteins containing a single thyroglobulin type-I domain. They are critical components in the processing of MHC class II antigen through forming a stabilizing complex following the alpha/beta heterodimer synthesis, and orchestrating complex trafficking away from the ER compartments in which class II peptide loading occurs.
      References
      Product Information
      FormatPurified
      Control
      • Mouse spleen tissue lysate
      PresentationPurified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect MHC class II (I-A/I-E) using this Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 validated for use in WB, FC, IH.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesFlow Cytometry Analysis: A previous lot was used by an independent laboratory in FC on spleen cells. (Bhattacharya, A., et al. (1981). The Journal of immunology. 127(6):2488-2496.)

      Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH on thymus tissue. (de Bont, E., et al. (1999). Int. Immunol. 11(8):1295-1306.)
      Biological Information
      ImmunogenB6 Anti-BNL4Φ lymphocytes
      CloneM5/114
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Ia-GAMMA
      • DHLAG
      • CD74
      • p33
      • HLADG
      • ii
      • Ii
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

      SUBUNIT STRUCTURE: Nonamer composed of three alpha/beta/gamma heterotrimers (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).

      SEQUENCE SIMILARITIES: Contains 1 thyroglobulin type-1 domain.
      Molecular Weight ~32 kDa observed.
      There are 2 isoforms produced by alternative splicing: 32 kDa Isoform Long and 24 kDa Isoform Short.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse spleen tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected MHC class II (I-A/I-E) in 10 µg of mouse spleen tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-MHC class II (I-A/I-E) Antibody, clone M5/114 試験成績書(CoA)

      タイトルロット番号
      Anti-MHC class II (I-A/I-E), clone -26607442660744
      Anti-MHC class II (I-A/I-E), clone -26838822683882
      Anti-MHC class II (I-A/I-E), clone -27463972746397
      Anti-MHC class II (I-A/I-E), clone -27949332794933
      Anti-MHC class II (I-A/I-E), clone M5/1142480863
      Anti-MHC class II (I-A/I-E), clone M5/114 - 23883282388328
      Anti-MHC class II (I-A/I-E), clone M5/114 - 24450472445047
      Anti-MHC class II (I-A/I-E), clone M5/114 - 20264092026409
      Anti-MHC class II (I-A/I-E), clone M5/114 - 20751382075138
      Anti-MHC class II (I-A/I-E), clone M5/114 - 21072642107264

      参考資料

      参考資料の概要Pub Med ID
      Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.
      Deleon-Pennell, KY; de Castro Brás, LE; Lindsey, ML
      Physiological reports  1  e00079  2013

      概要を表示する
      24159380 24159380

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies