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MABE324 Anti-MSH3 Antibody, clone 1F6

MABE324
100 µg  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE324
      DescriptionAnti-MSH3 Antibody, clone 1F6
      Alternate Names
      • DNA mismatch repair protein Msh3
      • Protein repair-1
      • REP-1
      • Protein repair-3
      • REP-3
      Background InformationMSH3, also known as DNA mismatch repair protein Msh3, Protein repair-1, REP-1, or Protein repair-3, REP-3, and encoded by the gene MSH3/REP-3, is an important component of the post-replicative DNA mismatch repair system. MSH3 heterodimerizes with MSH2 to form a complex named MutS beta which binds DNA mismatches and initiates DNA repair. MSH3/MSH2 complex (MutS beta) also complexes with another protein complex called MutL alpha which is also necessary for further steps in DNA repair. MSH3 is also frequently mutated in many cancers resulting in a mismatch repair deficiency and this can contribute to sensitivity to cytotoxic drugs. Interestingly too, because MSH3 is involved in DNA repair, it appears to it can mediate sensitivity to various repeat-associated diseases such as Huntington’s disease.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-MSH3 Antibody, clone 1F6 is validated for use in Western Blotting and Immunocytochemistry for the detection of MSH3.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: 0.5 µg/mL of this antibody detected MSH3 in 10 µg of mouse testis tissue lysate.

      Immunocytochemistry Analysis: A representative lot detected MSH3 in C2C12 cells (Prof. Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease.; Holt, I., et al. (2011). J Cell Biochem. 112(6):1612-1621.).
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse MSH3.
      Clone1F6
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Msh3
      • Rep-3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~123 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in C2C12 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected MSH3 in 10 µg of C2C12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-MSH3 Antibody, clone 1F6 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-MSH3 Antibody, clone 1F6 試験成績書(CoA)

      タイトルロット番号
      Anti-MSH3, clone 1F6 - Q2433685Q2433685
      Anti-MSH3, clone 1F6 - 33031043303104
      Anti-MSH3, clone 1F6 Monoclonal Antibody3140154

      参考資料

      参考資料の概要Pub Med ID
      The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.
      Holt, Ian, et al.
      J. Cell. Biochem., 112: 1612-21 (2011)  2011

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