Anti-N-CoR1, clone 7A7A9 Antibody

Nuclear receptor corepressor 1 (N-CoR or N-CoR1), and encoded by the gene name NCOR, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. N-CoR1 is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. N-CoR1 is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17.

270 kDa calculated

Purified recombinant fragment of human N-CoR1 expressed in E. Coli

Anti-N-CoR1, clone 7A7A9 Antibody detects level of N-CoR1 & has been published & validated for use in N-CoR1.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

Unpurified

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected N-CoR1 in human cerebra and breast carcinoma tissues.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.