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ABE868-25UG Anti-PGC-1 alpha

Anti-PGC-1 alpha, Cat. No. ABE868, is a highly specific rabbit polyclonal antibody that targets Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and has been tested for use in Immunocytochemistry and Western Blotting.

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Research Category: Epigenetics & Nuclear Function Gene Symbol: Ppargc1a, Pgc1, Pgc1a, Ppargc UniProt Number: O70343
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ABE868-25UG
25 μg  
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      概要

      Replacement Information

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE868-25UG
      DescriptionAnti-PGC-1 alpha
      Alternate Names
      • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
      • PPAR-gamma coactivator 1-alpha
      • PPARGC-1-alpha
      Background InformationPeroxisome proliferator-activated receptor gamma coactivator 1-alpha (UniProt: O70343; also known as PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha) is encoded by the Ppargc1a (also known as Pgc1, Pgc1a, Ppargc1) gene (Gene ID: 19017) in murine species. PGC-1 alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is a homooligomeric transcriptional coactivator for steroid receptors and nuclear receptors that greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. It is expressed in muscles, liver, kidney, brown adipose tissue, heart, and brain. It can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and is also reported to play an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. PGC-1 alpha is known to induce the expression of PPARGC1- and ESRR-induced regulator, muscle 1 (PERM1) in the skeletal muscle in an estrogen-related receptors, -alpha (ESRRA)-dependent manner. PGC-1 alpha is significantly induced in brown adipose tissue and skeletal muscle by exposure to cold and is also shown to be up-regulated in brown adipose tissue of obese leptin-deficient (ob/ob) and leptin-unresponsive (db/db) mice. PGC-1 alpha is also required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the co-activation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PGC-1 alpha, Cat. No. ABE868, is a highly specific rabbit polyclonal antibody that targets Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and has been tested for use in Immunocytochemistry and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot detected PGC-1 alpha in A431, HUVEC, and NIH/3T3 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 21 amino acids from the C-terminus region of murine PPAR-gamma coactivator 1-alpha.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects PGC-1 alpha in human and murine adipose tissue. it targets an epitope within 21 amino acids from the C-terminus region.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rat, Bovine, and Porcine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • Ppargc1a
      • Pgc1
      • Pgc1a
      • Ppargc
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~100 kDa observed; 90.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brown adipose tissue lysate.
      Western Blotting Analysis: 2 µg/mL of this antibody detected PGC-1 alpha in 10 µg of human brown adipose tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      ABE868-25UG 04054839539084