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MABE369 Anti-Suv4–20h2 Antibody, clone 6B9

MABE369
100 µg  
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      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB R Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE369
      DescriptionAnti-Suv4–20h2 Antibody, clone 6B9
      Alternate Names
      • Histone-lysine N-methyltransferase SUV420H2
      • Lysine N-methyltransferase 5C
      • Suppressor of variegation 4-20 homolog 2
      • Su(var)4-20 homolog 2
      • Suv4-20h2
      Background InformationSuppressor of variegation 4-20 homolog 2 (Suv4-20h2), also known as Lysine N-methyltransferase 5C (KMT5C), is a Histone-lysine N-methyltransferase that specifically trimethylates Lys-20 of histone H4. Suv4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. In mammals, Histone H4 Lys-20 trimethylation (H4K20me3) is one of the most common chromatin modifications and it has been implicated in various biological processes, including heterochromatin formation, telomere function, imprinting, X inactivation, DNA damage repair and cancer progression.
      References
      Product Information
      FormatPurified
      Control
      • H9 human embryonic stem cell lysate
      PresentationPurified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect the Suv4–20h2 protein using this Anti-Suv4–20h2, clone 6B9 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Suv4-20h2.
      Clone6B9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SUV420H2
      • KMT5C
      • PP7130
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~53 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~11 kDa and ~15 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in H9 human embryonic stem cell lysate.

      Western Blot Analysis: 4.0 µg/mL of this antibody detected Suv4-20h2 in 10 µg of H9 human embryonic stem cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Suv4–20h2 Antibody, clone 6B9 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-Suv4–20h2 Antibody, clone 6B9 試験成績書(CoA)

      タイトルロット番号
      Anti-Suv4#8211;20h2, clone 6B9 - Q2112550Q2112550
      Anti-Suv4–20h2, clone 6B9 - 32082113208211
      Anti-Suv4–20h2, clone 6B9 - 34577753457775
      Anti-Suv4–20h2, clone 6B9 Monoclonal Antibody2987952

      参考資料

      参考資料の概要アプリケーションPub Med ID
      Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
      Hahn, M; Dambacher, S; Dulev, S; Kuznetsova, AY; Eck, S; Wörz, S; Sadic, D; Schulte, M; Mallm, JP; Maiser, A; Debs, P; von Melchner, H; Leonhardt, H; Schermelleh, L; Rohr, K; Rippe, K; Storchova, Z; Schotta, G
      Genes & development  27  859-72  2013

      概要を表示する
      23599346 23599346
      CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
      Dambacher, S; Deng, W; Hahn, M; Sadic, D; Fröhlich, J; Nuber, A; Hoischen, C; Diekmann, S; Leonhardt, H; Schotta, G
      Nucleus (Austin, Tex.)  3  101-10  2012

      概要を表示する
      Immunofluorescence22540025 22540025

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies