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MABE330 Anti-c-ErbB2/c-Neu Antibody, clone 3B5

MABE330
100 µg  
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      概要

      Replacement Information

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      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE330
      Replaces04-1127
      DescriptionAnti-c-ErbB2/c-Neu Antibody, clone 3B5
      Alternate Names
      • Receptor tyrosine-protein kinase erbB-2
      • Metastatic lymph node gene 19 protein
      • MLN 19
      • Proto-oncogene Neu
      • Proto-oncogene c-ErbB-2
      • Tyrosine kinase-type cell surface receptor HER2
      • p185erbB2
      • CD340
      Background InformationThe ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. ErbB2 dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer.
      References
      Product Information
      FormatPurified
      Control
      • SK-BR-3 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-c-ErbB2/c-Neu Antibody, clone 3B5 is a Mouse Monoclonal Antibody for detection of c-ErbB2/c-Neu also known as MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2 or CD340, has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected c-ErbB2/c-Neu in human breast cancer tissue.
      Biological Information
      ImmunogenLinear peptide corresponding human c-ErbB2/c-Neu.
      Clone3B5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ERBB2
      • HER2
      • MLN19
      • NEU
      • NGL
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~185 kDa observed. Uniprot describes four isoforms at ~138 kDa (isoform 1), ~63 kDa (isoform 2), ~71 kDa (isoform 3), and ~137 kDa (isoform 4), which can be highly glycosylated and phosphorylated. This antibody may detect one or more isoforms. Uncharacterized bands may be observed at ~27 kDa and ~38 kDa in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in SK-BR-3 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected c-ErbB2/c-Neu in 10 µg of SK-BR-3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-c-ErbB2/c-Neu Antibody, clone 3B5 (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-c-ErbB2/c-Neu Antibody, clone 3B5 試験成績書(CoA)

      タイトルロット番号
      Anti-c-ErbB2/c-Neu, clone 3B Monoclonal Antibody2872225
      Anti-c-ErbB2/c-Neu, clone 3B52476787
      Anti-c-ErbB2/c-Neu, clone 3B5 - 32097573209757
      Anti-c-ErbB2/c-Neu, clone 3B5 - 34303133430313
      Anti-c-ErbB2/c-Neu, clone 3B5 - Q2010837Q2010837
      Anti-c-ErbB2/c-Neu, clone 3B5 -25443412544341
      Anti-c-ErbB2/c-Neu, clone 3B5 -25807262580726
      Anti-c-ErbB2/c-Neu, clone 3B5 Monoclonal Antibody2900038
      Anti-c-ErbB2/c-Neu, clone 3B5 Monoclonal Antibody3018915

      カタログ

      タイトル
      New Products: Volume 3, 2012

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies