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MABE433 Anti-phospho Histone H2B (Tyr37), clone 15 Antibody

MABE433
100 µg  
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      概要

      Replacement Information

      Special Offers[海外情報]

      主要スペック表

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, ChIP M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABE433
      DescriptionAnti-phospho Histone H2B (Tyr37), clone 15 Antibody
      Alternate Names
      • Histone H2B type 3-B
      • H2B type 12
      Background InformationHistones are basic nuclear proteins that are responsible for the nucleosome structure of chromatin in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which DNA is wrapped in repeating units, called nucleosomes. Histone H2B is one of the main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H2B is involved with the structure of the nucleosomes of the 'beads on a string' structure.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho Histone H2B (Tyr37) antibody, clone 15 is validated for use in western blotting & ChIP for the detection of phospho Histone H2B (Tyr37).
      Key Applications
      • Western Blotting
      • Chromatin Immunoprecipitation (ChIP)
      Application NotesChromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated phospho Histone H2B (Tyr37) in mouse MEF cells which were untreated or treated with WEE inhibitor (Mahajan, K., et al. (2012). Nat Struct Mol Biol. 19(9):930-937.).

      Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated phospho Histone H2B (Tyr37) in MEF-overexpressing WEE (Mahajan, K., et al. (2012). Nat Struct Mol Biol. 19(9):930-937.).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Histone H2B phosphorylated at Tyr37.
      Clone15
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST3H2BB
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~17 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected phospho Histone H2B (Tyr37) in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-phospho Histone H2B (Tyr37), clone 15 Antibody (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Anti-phospho Histone H2B (Tyr37), clone 15 Antibody 試験成績書(CoA)

      タイトルロット番号
      Anti-phospho Histone H2B (Tyr37), clone 15 - Q2385783Q2385783
      Anti-phospho Histone H2B (Tyr37), clone 15 -27077642707764
      Anti-phospho Histone H2B (Tyr37), clone 15 Monoclonal Antibody3128872
      Anti-phospho Histone H2B (Tyr37), clone 15 Monoclonal Antibody2979948

      参考資料

      参考資料の概要Pub Med ID
      H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes.
      Mahajan, Kiran, et al.
      Nat. Struct. Mol. Biol., 19: 930-7 (2012)  2012

      概要を表示する
      22885324 22885324

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      カテゴリー

      Life Science Research > Antibodies and Assays > Primary Antibodies