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178223 Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem

178223
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
37682-72-7C₂₇H₄₄N₁₀O₆ · 2HCl

価格&在庫状況

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178223-10MGCN
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      樹脂アンプル 10 mg
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      Description
      OverviewPeptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
      Effective concentration: 1-100 µM.
      Catalogue Number178223
      Brand Family Calbiochem®
      References
      ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
      Umezawa, H. 1976. Methods Enzymol. 55, 678.
      Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
      Product Information
      CAS number37682-72-7
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₂₇H₄₄N₁₀O₆ · 2HCl
      Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targettrypsin-like serine proteases, papain, and some cysteine proteases
      Primary Target IC<sub>50</sub>300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYV9350800
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      178223

      参考資料

      参考資料の概要
      Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
      Umezawa, H. 1976. Methods Enzymol. 55, 678.
      Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.

      引用

      Title
    • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
    • データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-September-2014 JSW
      DescriptionA reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
      FormWhite powder
      CAS number37682-72-7
      RTECSYV9350800
      Chemical formulaC₂₇H₄₄N₁₀O₆ · 2HCl
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml) or DMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
      Ichikawa, S., et al. 1985. J. Reprod. Fertil. 73, 385
      Umezawa, H. 1976. Methods Enzymol. 55, 678.
      Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
      Citation
    • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.