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341310 FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem

The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.

FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403

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341310
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
300657-03-8C₃₁H₂₆N₂O₃

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341310-5MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      OverviewA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      Catalogue Number341310
      Brand Family Calbiochem®
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      References
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      Product Information
      CAS number300657-03-8
      FormWhite solid
      Hill FormulaC₃₁H₂₆N₂O₃
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      341310-5MGCN 04055977215656

      Documentation

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      FABP4 Inhibitor - CAS 300657-03-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      341310

      参考資料

      参考資料の概要
      Furuhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2008 JSW
      Synonymsadipocyte Fatty-Acid-Binding Protein Inhibitor, ((2ʹ-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1ʹ-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
      DescriptionA cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number300657-03-8
      Chemical formulaC₃₁H₂₆N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml), Methanol (50 mg/ml), or Ethanol (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFuruhashi, M., et al. 2007. Nature 447, 959.
      Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3511.