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475874 MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem

A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [³H]LTD4 binding to human lung membranes).

MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: L 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt

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475874
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
115104-28-4C₂₆H₂₆ClN₂O₃S₂ • Na

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      Description
      OverviewA selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).
      Catalogue Number475874
      Brand Family Calbiochem®
      SynonymsL 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
      References
      ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
      Product Information
      CAS number115104-28-4
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₆H₂₆ClN₂O₃S₂ • Na
      Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
      HS Code2933 49 90
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAntagonist of leukotriene D4 (LTD4)
      Primary Target K<sub>i</sub>2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      475874-5MGCN 07790788050474

      Documentation

      MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MK571, Sodium Salt - CAS 115104-28-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      475874

      参考資料

      参考資料の概要
      Olson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsL 660711, Sodium Salt, (E)-3-[[[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-[[3-dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid, Sodium Salt
      DescriptionA selective, competitive antagonist of leukotriene D4 (LTD4) receptor (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).
      FormOff-white solid
      CAS number115104-28-4
      Chemical formulaC₂₆H₂₆ClN₂O₃S₂ • Na
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (200 mg/ml) or DMSO (10 mg/ml)
      Storage Protect from moisture
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
      Toxicity Standard Handling
      ReferencesOlson, D.P., et al. 2001. Cytometry 46, 105.
      Van der Kolk, D.M., et al. 1998. Clin. Cancer Res. 4, 1727.
      Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol. 67, 17.