517301 Sigma-AldrichP-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem
The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications. Less<<P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
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概要
| Replacement Information |
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主要スペック表
| CAS # | Empirical Formula |
|---|---|
| 864426-22-2 | C₂₃H₁₈ClNO₄ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
|---|---|---|---|---|---|---|
| 517301-10MGCN |
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樹脂ｱﾝﾌﾟﾙ | 10 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells. |
| Catalogue Number | 517301 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4 |
| References | |
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| References | Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782. |
| Product Information | |
|---|---|
| CAS number | 864426-22-2 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₃H₁₈ClNO₄ |
| Chemical formula | C₂₃H₁₈ClNO₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | P-Glycoprotein |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 517301-10MGCN | 04055977271874 |
Documentation
P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem (M)SDS
| タイトル |
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P-Glycoprotein Inhibitor, C-4 - CAS 864426-22-2 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 517301 |
参考資料
| 参考資料の概要 |
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| Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136. Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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