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528105 Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem

A potent antagonist of GABA receptors (IC₅₀ = 240 nM) at synapses in the central nervous system.

Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: GABA receptors
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528105
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
124-87-8C₁₅H₁₈O₇ . C₁₅H₁₆O₆

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528105-100MGCN
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      		 100 mg
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      Description
      OverviewA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl– channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
      Catalogue Number528105
      Brand Family Calbiochem®
      References
      ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
      Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
      Akaike, N., et al. 1985. Experientia 41, 70.
      Product Information
      CAS number124-87-8
      ATP CompetitiveN
      FormWhite to light yellow powder or crystals
      Hill FormulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
      Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABA receptors
      Primary Target IC<sub>50</sub>240 nM against GABA receptors
      Purity≥98% (mixture of Picrotoxin and picrotin) by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTJ9100000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      528105-100MGCN 04055977270488

      Documentation

      Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Picrotoxin, Anamirta cocculin - CAS 124-87-8 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      528105

      参考資料

      参考資料の概要
      Qian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
      Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
      Akaike, N., et al. 1985. Experientia 41, 70.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-March-2019 JSW
      DescriptionA potent antagonist of GABA receptors (IC50 = 240 nM) at synapses in the central nervous system. Inhibits 35S-TBPS binding to the Cl- channel (IC50 = 1.7 µM). Picrotoxin is a mixture of one mole of picrotoxinin and one mole of picrotin.
      FormWhite to light yellow powder or crystals
      CAS number124-87-8
      RTECSTJ9100000
      Chemical formulaC₁₅H₁₈O₇ . C₁₅H₁₆O₆
      Structure formulaStructure formula
      Purity≥98% (mixture of Picrotoxin and picrotin) by HPLC
      SolubilityEthanol (50 mg/ml) or basic aqueous solutions (3 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Toxicity Highly Toxic
      Merck USA index14, 7415
      ReferencesQian, H., and Dowling, J.E. 1994. J. Neurosci. 14, 4299.
      Yoon, K.W., et al. 1993. J. Physiol. 464, 423.
      Akaike, N., et al. 1985. Experientia 41, 70.