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539162 Proteasome Inhibitor II - Calbiochem

The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Proteasome Inhibitor II - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO

Primary Target: MPC
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539162
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概要

Replacement Information

主要スペック表

Empirical Formula
C₂₉H₃₉N₃O₅

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
539162-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      539162-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
          Catalogue Number539162
          Brand Family Calbiochem®
          Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
          References
          ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Orlowski, M., et al. 1993. Biochemistry 32, 1563.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₂₉H₃₉N₃O₅
          Chemical formulaC₂₉H₃₉N₃O₅
          ReversibleY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMPC
          Primary Target K<sub>i</sub>460 nM against the pituitary multicatalytic proteinase complex (MPC)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Leu-Leu-Phe-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          539162-1MGCN 04055977269451
          539162-5MGCN 04055977269468

          Documentation

          Proteasome Inhibitor II - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          Proteasome Inhibitor II - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          539162

          参考資料

          参考資料の概要
          Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Orlowski, M., et al. 1993. Biochemistry 32, 1563.

          カタログ

          タイトル
          Caspases and other Apoptosis Related Tools Brochure
          Proteasomes Technical Bulletin
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-September-2008 RFH
          Synonyms(Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
          DescriptionA potent and cell-permeable proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidylglutamyl-peptide hydrolyzing (PGPH) activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
          FormWhite lyophilized solid
          Chemical formulaC₂₉H₃₉N₃O₅
          Peptide SequenceZ-Leu-Leu-Phe-CHO
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
          Toxicity Standard Handling
          ReferencesSchauer, S.L., et al. 1998. J. Immunol. 160, 4398.
          Orlowski, M., et al. 1997. Biochemistry 36, 13946.
          Orlowski, M., et al. 1993. Biochemistry 32, 1563.