Millipore Sigma Vibrant Logo

654255 TNF-α Antagonist - Calbiochem

The TNF-α Antagonist controls the biological activity of TNF-α.

TNF-α Antagonist - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I

Primary Target: TNF-α
View This Product on Sigma-Aldrich
654255
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical Formula
C₅₈H₇₁N₁₁O₁₅S₂

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
654255-1MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 1 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.
      Catalogue Number654255
      Brand Family Calbiochem®
      SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
      References
      ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,265,535.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₈H₇₁N₁₁O₁₅S₂
      Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α
      Primary Target IC<sub>50</sub>5 µM as TNF-α antagonist
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      654255-1MGCN 04055977184624

      Documentation

      TNF-α Antagonist - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      TNF-α Antagonist - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      654255

      参考資料

      参考資料の概要
      Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-November-2013 JSW
      SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
      DescriptionAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
      Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml) or 5% Acetic Acid (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.