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654164 Tubulin Polymerization Inhibitor II

The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.

Tubulin Polymerization Inhibitor II: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one

Primary Target: Purified porcine brain tubulin
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654164
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
1151995-69-5C₁₉H₁₉NO₅

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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      OverviewA cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested).
      Catalogue Number654164
      Brand Family Calbiochem®
      Synonyms(E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
      References
      ReferencesPandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.
      Product Information
      CAS number1151995-69-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₉NO₅
      Chemical formulaC₁₉H₁₉NO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPurified porcine brain tubulin
      Primary Target IC<sub>50</sub>4.5 µM in inhibiting polymerization of purified porcine brain tubulin
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      654164-5MGCN 04055977184587

      Documentation

      Tubulin Polymerization Inhibitor II (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Tubulin Polymerization Inhibitor II 試験成績書（CoA）

      タイトルロット番号
      654164

      参考資料

      参考資料の概要
      Pandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms(E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
      DescriptionA cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1151995-69-5
      Chemical formulaC₁₉H₁₉NO₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesPandit, B., et al. 2006. Bioorg. Med. Chem. 14, 6492.
      Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5382.