05-23-0050
Corticotropin Releasing Factor, Human and Rat
An immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla.
別名:
Corticotropin Releasing Factor, Human and Rat, CRF, CRH, Corticotropin-releasing hormone
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この商品について
実験式（ヒル表記法）:
C208H344N60O63S2
CAS番号:
分子量:
4757.45
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Assay:
≥97% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
Quality Segment
assay
≥97% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
technique(s)
cell based assay: suitable
color
white to off-white
solubility
5% NH4OH: 1 mg/mL (prepared with H₂O)
shipped in
ambient
storage temp.
−20°C
InChI key
VXFVFWFSJFSXHN-FAUHKOHMSA-N
Gene Information
human ... CRH(1392)
General description
Research area: Neuroscience
Corticotropin-releasing factor (CRF), a 41-amino-acid peptide, is widely expressed in neurons throughout the mammalian brain and several peripheral tissues such as the pancreas, stomach, and small intestine. It functions by stimulating the secretion of corticotropin in the anterior pituitary, which in turn regulates adrenal cortex synthetic/secretory activity. Human CRF is located on chromosome 8q13 and is identical to rat and mouse CRF. It assumes a random coil structure under physiological conditions and α-helix shape in an amphiphilic environment.
Corticotropin-releasing factor (CRF), a 41-amino-acid peptide, is widely expressed in neurons throughout the mammalian brain and several peripheral tissues such as the pancreas, stomach, and small intestine. It functions by stimulating the secretion of corticotropin in the anterior pituitary, which in turn regulates adrenal cortex synthetic/secretory activity. Human CRF is located on chromosome 8q13 and is identical to rat and mouse CRF. It assumes a random coil structure under physiological conditions and α-helix shape in an amphiphilic environment.
Application
Corticotropin-releasing factor (CRF) has been used to investigate its effects on Cerebellar Motor Control and Ataxia in rats.
Biochem/physiol Actions
Cell permeable: no
Primary Target: An immunomodulatory neuropeptide
The product does not compete with ATP.
Reversible: no
Corticotropin-releasing factor (CRF), a neuropeptide also known as corticotropin-releasing factor (CRH), plays a crucial role in the stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis and extrahypothalamic pathways. It acts by releasing Adrenocorticotropic Hormone (ACTH) from the anterior pituitary, stimulating the sympathetic nervous system and adrenal medulla. Besides its involvement in stress regulation, CRF peptides have diverse effects on both, the central nervous system and peripheral tissues. This includes potential regulation of anxiety, mood, feeding, inflammation, gastric emptying, and blood pressure. Aberrant secretion of CRF could potentially contribute to the development of various neuropsychiatric disorders such as anxiety, depression, obsessive-compulsive disorder, Parkinson′s disease, Alzheimer′s disease, alcohol withdrawal, and post traumatic stress disorder. Also, CRF and CRF-R1 (Corticotropin-Releasing Factor Receptor 1) have been observed in lymphoid organs and sites of inflammation, suggesting a role in immune system regulation.
Primary Target: An immunomodulatory neuropeptide
The product does not compete with ATP.
Reversible: no
Corticotropin-releasing factor (CRF), a neuropeptide also known as corticotropin-releasing factor (CRH), plays a crucial role in the stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis and extrahypothalamic pathways. It acts by releasing Adrenocorticotropic Hormone (ACTH) from the anterior pituitary, stimulating the sympathetic nervous system and adrenal medulla. Besides its involvement in stress regulation, CRF peptides have diverse effects on both, the central nervous system and peripheral tissues. This includes potential regulation of anxiety, mood, feeding, inflammation, gastric emptying, and blood pressure. Aberrant secretion of CRF could potentially contribute to the development of various neuropsychiatric disorders such as anxiety, depression, obsessive-compulsive disorder, Parkinson′s disease, Alzheimer′s disease, alcohol withdrawal, and post traumatic stress disorder. Also, CRF and CRF-R1 (Corticotropin-Releasing Factor Receptor 1) have been observed in lymphoid organs and sites of inflammation, suggesting a role in immune system regulation.
Packaging
Yes
Physical form
Supplied as an acetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Barmack, N.H., and Errico, P. 1993. J. Neurosci. 13, 4647.
Wei, E.T., et al. 1993. Ciba Found. Symp. 172, 258.
Smith, E.M., et al. 1986. Nature321, 881.
Udelsman, R., et al. 1986. Nature319, 147.
Wei, E.T., et al. 1993. Ciba Found. Symp. 172, 258.
Smith, E.M., et al. 1986. Nature321, 881.
Udelsman, R., et al. 1986. Nature319, 147.
H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH₂
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
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