119147
8-シクロペンチル-1,3-ジプロピルキサンチン
DPCPX
別名:
1,3-ジプロピル-8-シクロペンチルキサンチン, DPCPX, PD 116,948
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この商品について
実験式（ヒル表記法）:
C16H24N4O2
CAS番号:
分子量:
304.39
UNSPSC Code:
12352200
NACRES:
NA.51
MDL number:
Form:
white solid
Quality Segment
form
white solid
solubility
soluble (DMSO (5 mM))
storage temp.
2-8°C
SMILES string
CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3
InChI
1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChI key
FFBDFADSZUINTG-UHFFFAOYSA-N
General description
A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.