Anti-ASC Antibody

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.

Peptide corresponding to aa 182-195 (RESQSYLVEDLERS) of human ASC.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-ASC Antibody is validated for use in WB for the detection of ASC.

Western blot: 1:500

HL60 whole cell lysate can be used as a positive control.

Optimal working dilutions must be determined by end user.

Detects a 25 kDa band by western blot, corresponding to ASC/TMS1.

Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Format: Purified

Maintain at 4°C for up to 6 months.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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