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ABE1000

Anti-FOXM1 Antibody

Name: Anti-FOXM1 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

別名:

Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, HFH-11, HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor fr

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この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, IP, WB

Citations:

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特性

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

species reactivity (predicted by homology)

canine (based on 100% sequence homology), monkey (based on 100% sequence homology), primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

NCBI accession no.

NP_973732

UniProt accession no.

Q08050

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FOXM1(2305), MPP2(4355)

詳細

General description

Forkhead box M1 (FOXM1), also named HNF-3, HFH-11 or Trident, belongs to a superfamily of Fox transcription factors. FOXM1 is strongly associated with cell proliferation and plays an important role in cell cycle progression by regulating both G1/S and G2/M phases. FOXM1 is also involved in DNA damage repair, angiogenesis, apoptosis, and tissue regeneration. Recently, crucial roles of this transcription factor were found in the development and progression of many cancers including colorectal, lung, prostate, liver and breast cancer. FOXM1 levels are significantly higher and associated with tumor grade in most human tumors, rendering it a potential target of cancer diagnosis and therapies.

~88 kDa observed

Immunogen

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to a region near the C-terminus of human FOXM1.

Application

Anti-FOXM1 Antibody is an antibody against FOXM1 for use in western blotting, IHC & IP.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FOXM1 in human testis tissue.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Biochem/physiol Actions

This antibody is expected to detect three known isoforms of FOXM1 based upon immunogen design.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in human thymus tissue lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected FOXM1 in 10 µg of human thymus tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c