ABS986
Anti-PCTP Antibody
serum, from rabbit
別名:
Phosphatidylcholine transfer protein, PC-TP, START domain-containing protein 2, StARD2, StAR-related lipid transfer protein 2
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IP, WB
Citations:
2
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PCTP(58488)
General description
Phosphatidylcholine transfer protein (PCTP), also known as PC-TP, START domain-containing protein 2, StARD2, StAR-related lipid transfer protein 2, and encoded by the gene symbol PCTP/ STARD2, belongs to the steroidogenic acute regulatory protein related transfer (START) domain superfamily of hydrophobic ligand-binding proteins. PCTP has been shown to play an important role in the transfer of phosphatidylcholine between membranes. The crystal structures of human PC-TP in complex with dilinoleoyl-PtdCho or palmitoyl-linoleoyl-PtdCho suggests that a single well-ordered PtdCho molecule occupies a centrally located tunnel. These structures have provided a basis for rationalizing the specificity of PC-TP for PtdCho and may identify common features used by START proteins to bind their hydrophobic ligands. Additionally, PCTP has been demonstrated to interact with ACOT13/THEM2. PCTP is located in the cytoplasm with highest expression in liver, placenta, testis, kidney and heart. Low levels of PCTP are expressed in brain and lung.
~33 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human PCTP.
Application
Anti-PCTP is an antibody against PCTP for use in WB, ICC, IP.
Western Blotting Analysis: A representative lot detected PCTP in cytosolic fractions isolated from the liver of a control subject, a patient with intrahepatic brown pigment stones, and a patient with obstructive cholestasis (Shoda, J., et al. (2001). Hepatology. 33(5):1194-1205).
Western Blotting Analysis: A representative lot detected PCTP in siRNA-transfected, serum-starved HEK 293E cells, Pctp+/+ liver lysates, Tsc2−/− MEFs, Liver homogenates from chow diet–fed Pctp+/+ (n = 4) and Pctp−/− (n = 4) mice (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).
Immunocytochemistry Analysis: A representative lot detected PCTP in HEK293T cells (Kanno, K., et al. (2007). J. Biol. Chem. 282:30728-30736).
Immunoprecipitation Analysis: A representative lot immunoprecipitated PCTP in Pctp+/+ liver lysates (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).
Western Blotting Analysis: A representative lot detected PCTP in siRNA-transfected, serum-starved HEK 293E cells, Pctp+/+ liver lysates, Tsc2−/− MEFs, Liver homogenates from chow diet–fed Pctp+/+ (n = 4) and Pctp−/− (n = 4) mice (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).
Immunocytochemistry Analysis: A representative lot detected PCTP in HEK293T cells (Kanno, K., et al. (2007). J. Biol. Chem. 282:30728-30736).
Immunoprecipitation Analysis: A representative lot immunoprecipitated PCTP in Pctp+/+ liver lysates (Ersoy, B.A., et al. (2013). Science Signaling. 286(6):1-11).
Analysis Note
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PCTP in 5 µg of HepG2 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PCTP in 5 µg of HepG2 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Still not finding the right product?
製品選択ツール}で選択肢を絞り込んでください。
保管分類
10 - Combustible liquids
wgk
WGK 1
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。