Laminin-Specific Integrins Investigator Kit

Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The kit is designed for research focusing on integrins which are known to interact with Laminin. These include alpha1, alpha2, alpha3, alpha6, and alpha7 (not included with kit) which combine with the integrin beta1 subunit. The alpha6 subunit is also known to combine with the beta4 subunit. [Hynes, R. 1992. Cell 69:11-25]

Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

Chemicon offers the Laminin-Specific Integrins Investigator Kit for initial studies of Integrin/Laminin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.

Research Category
Cell Structure

Research Sub Category
Integrins

Chemicon′s Laminin Specific Integrins Kit (ECM420) is useful for the study of Laminin-associated integrins. Chemicon′s ECM420 kit provides 20 μg each of monoclonals to alpha1, alpha2, alpha3, alpha6, beta1, and beta4.

Store antibodies at -20°C.

Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liqu

alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 μg.
alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg.
alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg.
alpha6 Rat Monoclonal Antibody (Part No. MAB1378-20)- 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
beta4 Mouse Monoclonal Antibody (Part No. MAB2058-20) - 1 tube, 20 μg.

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