MAB2641
Anti-Fibrillin (Pan) Antibody, clone 689
clone 689, from mouse
別名:
EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
689, monoclonal
Application:
ELISA, IHC
Citations:
2
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
689, monoclonal
species reactivity
mouse
species reactivity (predicted by homology)
chicken (based on 100% sequence homology), human (based on 100% sequence homology)
technique(s)
ELISA: suitable, immunohistochemistry: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... EFEMP1(2202)
General description
Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.
~ 350 kDa calculated
Immunogen
Recombinant protein corresponding to human Fibrillin 3.
Application
Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.
ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).
Biochem/physiol Actions
The antibody recognizes isoforms 1, 2, and 3 of fibrillin.
Physical form
Format: Purified
Analysis Note
Control
Mouse skin tissue
Mouse skin tissue
Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.
Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.
Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
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MAB2641:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。