コンテンツへスキップ
Merck

主要文書

すべての文書を表示

MAB348A4

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.

clone 22C11, from mouse, ALEXA FLUOR™ 488

別名:

Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
22C11, monoclonal
Application:
ICC, IHC
Citations:
3
テクニカルサービス
お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。
お手伝いします

biological source

mouse

Quality Segment

100

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

22C11, monoclonal

species reactivity

rat, pig

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), porcine (based on 100% sequence homology), human (based on 100% sequence homology), canine (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable

isotype

IgG1

NCBI accession no.

NP_000475

UniProt accession no.

P05067

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... APP(351)

General description

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged human and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.
Reacts with pre-A4. The unconjugated antibody (MAB348) recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000).

Immunogen

Epitope: a.a. 66-81 of APP (N-terminus)

Application

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj. is an antibody against Alzheimer Precursor Protein A4 for use in IHC, ICC.
Immunohistochmeistry Analysis: A 1:50 dilution from a representative lot detected Alzheimer Precursor Protein A4 in adult mouse brain tissue.

Biochem/physiol Actions

Unconjugated MAB348 recognizes N-terminal amino acids 66-81 on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP: immature, ~110kDa; sAPP, ~120kDa; and mature, ~130kDa (Hoffmann et al., 2000). This antibody is known to cross react with APLP2 (Slunt, 1994).

Analysis Note

Evaluated by Immunocytochemistry in mouse N1E-115 neuroblastoma cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in mouse N1E-115 neuroblastoma cells.
Control
Mouse N1E-115 neuroblastoma cells

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Still not finding the right product?

製品選択ツール}で選択肢を絞り込んでください。

保管分類

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

MAB348A4:

jan

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする