MABC189
Anti-PIDD Antibody, clone 1511.1
clone 15F11.1, from mouse
別名:
p53-induced protein with a death domain, Leucine-rich repeat and death domain-containing protein, PIDD
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
15F11.1, monoclonal
Application:
ICC, WB
Citations:
-
biological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
15F11.1, monoclonal
species reactivity
rat, mouse, human
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PIDD1(55367)
General description
p53-induced protein with a death domain (PIDD) is also called Leucine-rich repeat and death domain-containing protein (LRDD). PIDD is involved in apoptosis downstream of the tumor suppressor. PIDD is a component of the DNA damage/stress response pathway in which p53/TP53 is associated with apoptosis. PIDD also aids in the activation of the transcription factor NF-kappa-B, and CASP2 which regulates apoptotic pathways.
~66 kDa observed. Uniprot describes 7 different isoforms.
Immunogen
Recombinant protein corresponding to human PIDD.
Application
Anti-PIDD Antibody, clone 1511.1 is a highly specific mouse monoclonal antibody, that targets p53-induced protein with a death domain & has been tested in western blotting & ICC.
Western Blotting Analysis: 1 µg/mL from a representative lot detected PIDD in 10 µg of NIH/3T3 and PC-12 cell lysate.
Immunohistochemistry Analysis: A 1:100 dilution, a 1:500 dilution, and a 1:1,000 dilution detected PIDD in HeLa, A431, and NIH/3T3 cells.
Immunohistochemistry Analysis: A 1:100 dilution, a 1:500 dilution, and a 1:1,000 dilution detected PIDD in HeLa, A431, and NIH/3T3 cells.
Biochem/physiol Actions
This antibody demonstrates specificity for isoform 4, but may detect isoform 1, 2 and 3. It will not detect isoforms 5, 6, and 7 based upon immunogen design.
Physical form
Format: Purified
Purified mouse IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Analysis Note
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PIDD in 10 µg of HeLa cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected PIDD in 10 µg of HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable