MABS1161
Anti-PYCR1 Antibody, clone 2D9.1
clone 2D9.1, from mouse
Sinónimos:
Pyrroline-5-carboxylate reductase 1, mitochondrial, PYCR1, P5C reductase 1, P5CR 1
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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2D9.1, monoclonal
Application:
IHC, WB
Citations:
-
Servicio técnico
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Permítanos ayudarlebiological source
mouse
Quality Segment
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
2D9.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... PYCR1(5831)
General description
Pyrroline-5-carboxylate reductase 1, mitochondrial (EC 1.5.1.2; UniProt P32322; also known as P5C reductase 1, P5CR 1) is encoded by the PYCR1 (also known as ARCL2B, ARCL3B) gene (Gene ID 5831) in human. Pyrroline-5-carboxylate (P5C) reductase (PYCR1) is a mitochondrial enzyme that utilizes NAD(P)H as cofactor and catalyzes the convertion of P5C to L-proline, as well as the coversion of Δ1-piperideine-6-carboxylate (P6C) to L-pipecolic acid, both of which are intermediates in the catabolism pathway of the essential amino acid L-lysine. PYCR1 gene mutations are associated with the autosomal recessive disorder cutis laxa type II, menifested with premature aging features such as joint laxity and wrinkled/lax skin, as well as developmental delay.
~33 kDa observed. 33.36 kDa (isoform 1) and 35.98 kDa (isoform 2) calculated. Uncharacterized band(s) may appear in some lysates. Uncharacterized band(s) may appear in some lysates.
Immunogen
GST-tagged recombinant protein corresponding to the C-terminal of human PYCR1.
Application
Anti-PYCR1 Antibody, clone 2D9.1 is an antibody against PYCR1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Biochem/physiol Actions
Expected to react with spliced isoforms 1 and 3, but not isoform 2, reported by UniProt P32322).
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected PYCR1 in 10 µg of K562 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected PYCR1 in 10 µg of K562 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
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Clase de almacenamiento
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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