IL-23, Human

Bioactivity assay: Determined by the dose-dependent secretion of h-IFN-gamma from human PBMC. ED50 is typically 2-20 ng/ml.

HumanKine IL-23 is manufactured using all non-animal reagents and is considered Xeno-Free

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.

Interleukin-23 (IL-23) is a heterodimer, the combination of IL-23-specific subunit p19 and IL-12 subunit p40 comprise the biologically active protein. Like IL-12, IL-23 has been shown to activate the transcription factor STAT4 (signal transducer and activator of transcription-4). Unlike IL-12, IL-23 also seems to play a role in the signaling of memory T cells. IL-23, in conjunction with IL-17, is important in controlling the bacterial growth and inflammation response in an organism with tuberculosis. It has the ability to induce Th17 activation and stimulate inflammation in many tissue types including periodontal lesions.

Product is presented in PBS and filtered through a 0.2 micron filter before lyophilization.

Store at -20°C for up to 4 months from date of receipt. Further dilutions should be made into appropriate buffer or medium to which protein has been added.

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc