572631
SU5402
InSolution, ≥95%, Inhibits the tyrosine kinase activity of FGFR1
동의어(들):
InSolution SU5402, SU5402
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C17H16N2O3
NACRES:
NA.77
UNSPSC Code:
12352200
제품 이름
SU5402, InSolution, ≥95%, Inhibits the tyrosine kinase activity of FGFR1
assay
≥95% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
storage temp.
−70°C
Quality Level
Disclaimer
Toxicity: Irritant (B)
General description
Inhibits the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP) by interacting with the catalytic domain of FGFR1. Also inhibits aFGF-induced phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984, it acts only as a weak inhibitor of tyrosine phosphorylation of the PDGF receptor. Does not inhibit the phosphorylation of insulin receptor and exhibits no inhibitory effect on EGF receptor kinase.
Legal Information
Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Mohammadi, M., et al. 1997. Science 276, 955.
Packaging
Packaged under inert gas
Physical form
A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572630) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
저장 등급
10 - Combustible liquids
wgk
WGK 1
flash_point_f
188.6 °F - (refers to pure substance)
flash_point_c
87 °C - (refers to pure substance)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Lydvina Meister et al.
Development (Cambridge, England), 149(10) (2022-05-17)
The fibroblast growth factor (FGF) signalling pathway plays various roles during vertebrate embryogenesis, from mesoderm formation to brain patterning. This diversity of functions relies on the fact that vertebrates possess the largest FGF gene complement among metazoans. In the cephalochordate
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 572631-500UGCN | 04055977266276 |
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